Calcium montmorillonite clay reduces urinary biomarkers of fumonisin B1 exposure in rats and humans

CRSP:   |  Region:   |  Topic:   |  Database:

A. Robinson; N. Johnson; A. Strey; J. Taylor; A. Marroquin-Cardona; N. Mitchell; E. Afriyie-Gyawu; N. Ankrah; J. Williams; J-S. Wang; P. Jolly; R. Nachman; T. Phillips

Type of Document:
Scholarly Article


Food Additives and Contaminants

Date of Publication:

Place of Publication:
Not Available


Abstract: Fumonisin B1 (FB1) is often a co-contaminant with aflatoxin (AF) in grains and may enhance AF’s

carcinogenicity by acting as a cancer promoter. Calcium montmorillonite (i.e. NovaSil, NS) is a possible dietary

intervention to help decrease chronic aflatoxin exposure where populations are at risk. Previous studies show that

an oral dose of NS clay was able to reduce AF exposure in a Ghanaian population. In vitro analyses from our

laboratory indicated that FB1 (like aflatoxin) could also be sorbed onto the surfaces of NS. Hence, our objectives

were to evaluate the efficacy of NS clay to reduce urinary FB1 in a rodent model and then in a human population

highly exposed to AF. In the rodent model, male Fisher rats were randomly assigned to either FB1 control,


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