The goals of this project are to extend the work conducted during previous cycles of support through the Peanut CRSP. We have demonstrated that peanuts pose little challenge to energy balance. The goals for the upcoming three years are to: A) Evaluate a likely mechanism for this effect; B) Explore the factors that may aid or discourage chronic peanut consumption; and C) Train researchers in our host country and the US in methods for clinical research.
1. Document the effects of peanuts on gut satiety peptide release, reward system activity (hedonics) and GI transit. 2. Determine compliance with a recommendation for chronic inclusion of single versus varied forms (i.e., sensory properties) of peanuts in the diet among individuals with different characteristics (e.g., flavor preferences, cognitive restrained, variety seeking). 3. Train investigators in human clinical research methods. 4. A new clinical trial is planned for this year in Brazil . The goal is to assess the effect of daily peanut (commercial unpeeled and peeled peanuts) consumption (8 weeks) on: intestinal permeability, gut microbiota, inflammatory and oxidative biomarkers.