Publication
Calcium montmorillonite clay reduces urinary biomarkers of fumonisin B1 exposure in rats and humans
Details
Author(s):
A. Robinson; N. Johnson; A. Strey; J. Taylor; A. Marroquin-Cardona; N. Mitchell; E. Afriyie-Gyawu; N. Ankrah; J. Williams; J-S. Wang; P. Jolly; R. Nachman; T. Phillips
Type of Document:
Scholarly Article
Publisher/Journal:
Food Additives and Contaminants
Date of Publication:
2012
Place of Publication:
Not Available
Links
Description
Abstract: Fumonisin B1 (FB1) is often a co-contaminant with aflatoxin (AF) in grains and may enhance AF’s
carcinogenicity by acting as a cancer promoter. Calcium montmorillonite (i.e. NovaSil, NS) is a possible dietary
intervention to help decrease chronic aflatoxin exposure where populations are at risk. Previous studies show that
an oral dose of NS clay was able to reduce AF exposure in a Ghanaian population. In vitro analyses from our
laboratory indicated that FB1 (like aflatoxin) could also be sorbed onto the surfaces of NS. Hence, our objectives
were to evaluate the efficacy of NS clay to reduce urinary FB1 in a rodent model and then in a human population
highly exposed to AF. In the rodent model, male Fisher rats were randomly assigned to either FB1 control,
FB1
