Publication
Relationship between aflatoxin B1 albumin adducts in plasma, aflatoxin M1 in urine and vitamin A and E levels in Ghanaians
Details
Author(s):
F. Obuseh; P.E. Jolly; Y. Jiang; F. Shuaib; J. Waterbor; W.O. Ellis; C. Piyathilake; W.O. Ellis; R.A. Desmond; E. Afriyie-Gyawu; T. Phillips
Type of Document:
Scholarly Article
Publisher/Journal:
International Journal of Vitamin and Nutrition Research
Date of Publication:
2010
Place of Publication:
Not Available
Links
Description
Abstract: Background–Although aflatoxin exposure has been shown to be associated with micronutrient
deficiency in animals, there are few investigations on the effects of aflatoxin exposure on micronutrient metabolism in humans. objectives–To examine the relationship between aflatoxin B1 (AFB1) albumin adducts (AFALB) in plasma and the aflatoxin M1 (AFM1) metabolite in urine and plasma concentrations of retinol (vitamin A) and ?-tocopherol (vitamin E) in Ghanaians. Methods–A cross-sectional study of 147 adult participants was conducted. Blood and urine samples were tested for aflatoxin and vitamins A and E levels. Results–Multivariable analysis showed that participants with high AF-ALB (? 0.80 pmol/mg albumin) had increased odds of having vitamin A deficiency compared to those with lower AFALB [Odds Ratio (OR) = 2.61; CI = 1.03
