Aflatoxin and PAH exposure biomarkers in a U.S. population with a high incidence of hepatocellular carcinoma

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N.M. Johnson; G. Qian; L. Xu; D. Tietze; A. Marroquin-Cardona; A. Robinson; M. Rodriquez; L. Kaufman; K. Cunningham; J. Wittmer; F. Guerra; K.C. Donnelly; J.H. Williams; J.S. Wang; T.D. Phillips

Type of Document:
Scholarly Article


Science of the Total Environment

Date of Publication:

Place of Publication:
Not Available


Abstract: The incidence of hepatocellular carcinoma (HCC) is significantly elevated in a Hispanic community in Bexar County, Texas. Chronic exposure to dietary aflatoxins (AFs) is a major risk factor for HCC; increased risk has been linked to polycyclic aromatic hydrocarbon (PAH) coexposure and hepatitis virus infection. The aims of this study were to assess AF and PAH exposures, investigate dietary factors that may contribute to increased AF exposure, and determine the prevalence of hepatitis virus infection in Bexar Co. Blood and urine samples were collected from 184 volunteers for biomarker analyses and hepatitis screening. Serum AFB1-lysine adduct, urinary AFM1 and 1-hydroxypyrene (1-OHP) levels were measured using high-performance liquid chromatography. The average AFB1-lysine adduct level detected in 20.6% of serums was 3.84

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